Prof. PALLU REDDANNA

PROJECT COORDINATOR

Prof. P. Reddanna has been working for the past 30 years in the area of inflammation and cancer. He has standardized assay methods for lipoxygenase and cyclooxygenases, the target enzymes for the development of anti-inflammatory and anti-cancer drugs, their cloning, expression, purification and characterization. His papers on leukotriene synthesis along with
Prof. E.J. Corey, the Nobel Laureate and the discovery of a new pathway for the conversion of
Leukotriene C4 to Leukotriene F4 are significant contributions. He has shown that Vitamin E
inhibits 5-lipoxygenase for the first time. In collaboration with NCL, Pune, he has developed
potent lipoxygenase inhibitor. He has provided scientific evidence for “Bronco-T”, an
Ayurvedic product developed by M/S Surya pharmaceuticals, for the treatment of allergy and
asthma. His group has proved that C-Phycocyanin and vitamin-D analogs are selective inhibitors
of Cyclooxygenase-2, which induce apoptosis in cancer cell lines. He is the first one to initiate
university-industry collaborations and receive the grant from DST under the program of Drugs &
Pharmaceuticals (now PDRSF). He has completed two projects for Dr Reddy’s Laboratories and
one project each to Shantha Biotechnics Pvt. Ltd., Indian Immunologicals (ivermectins),
Medgene Biotech, Surya Pharmaceuticals (Bronco T), Pacific Hospital Pvt Ltd., Dabur Research
Foundation, Natco Pharma & Laila Impex. He has conducted a DBT- sponsored short-term
training course on PUFAs and Eicosanoids, which was attended by representatives from
industries, research institutes, corporate hospitals and universities. He has helped Natco Pharma
in the development of potent Gleevec analogs for CML. Technologies were developed to
improve the shelf life of tomato and custard apple in collaboration with ANGRAU, as part of
AP-Netherlands Biotech program. Recognizing these achievements, Chemtech Foundation has
awarded the “Pharmabio Excellency Award” in 2005, Royan International Foundation,
awarded the “Royan Best Researcher Award” in 2007 and Federation of Andhra Pradesh
Chambers of Commerce and Industry (FAPCCI)
He has published around 150 papers in peer reviewed journals; Guided 30 students for
Ph.D. and trained more than 100 students for M. Sc. Projects. Already completed 20 projects
funded by Government agencies like DST, DBT, CSIR, UGC and ICMR, International agencies.
He also has undertaken projects from leading Pharma and biotech companies like Dr.Reddy’s
Labs, Dabur Research Foundation, Indian Immunologicals, Shantha Biotech, Natco Pharma,
Onconova, ABL Technologies, Surya Pharmaceuticals, Celestial Labs, Laila Impex etc.

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